Anti-Occludin Antibody [JJ091-08]
ET1701-76
ApplicationsFlow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse
TargetOcln
Overview
- SupplierHUABIO
- Product NameAnti-Occludin Antibody [JJ091-08]
- Delivery Days Customer7
- ApplicationsFlow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
- Applications SupplierWB,IP,FC
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDJJ091-08
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID18260
- Target nameOcln
- Target descriptionoccludin
- Target synonymsOcl, occludin
- HostRabbit
- IsotypeIgG
- Protein IDQ16625
- Protein NameOccludin
- Scientific DescriptionOccludin is an integral membrane protein closely associated with the tight junctions of epithelial and endothelial cells. Occludin is a tetraspan integral membrane protein in epithelial and endothelial tight junction (TJ) structures that can contain two extracellular loops. The protein exists in a variety of phosphorylated forms. Phosphorylation is involved in regulating both the localization and the function of occludin. Expression of occludin is up-regulated by poly-unsaturated fatty acids, increasing transendothelial cell resistance and reducing cellular permeability to large molecules. The level of occludin varies greatly depending on tissue; in brain tissue, occludin is highly expressed at cell-cell contact sites. Non-neural tissues show lower expression and discontinuous distribution. Up-regulation of epithelial occludin may play a role in enhancing paracellular permeability and be related to the damage to the tight junction.
- ReactivityHuman, Mouse
- Reactivity SupplierHuman,Mouse
- Storage Instruction-20°C,2°C to 8°C
- UNSPSC41116161