Anti-Olig2 Antibody [SP07-02]

HUABIO

Anti-Olig2 Antibody [SP07-02]

7

ImmunoFluorescence, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin, Other Application

WB,IHC-P

Research Use Only

Monoclonal

SP07-02

1 mg/ml

Unconjugated

OLIG2

oligodendrocyte transcription factor 2

BHLHB1, OLIGO2, PRKCBP2, RACK17, bHLHe19, oligodendrocyte transcription factor 2, basic domain, helix-loop-helix protein, class B, 1, class B basic helix-loop-helix protein 1, class E basic helix-loop-helix protein 19, human protein kinase C-binding protein RACK17, oligodendrocyte lineage transcription factor 2, oligodendrocyte-specific bHLH transcription factor 2, protein kinase C-binding protein 2

Rabbit

IgG

Oligodendrocyte transcription factor 2

The oligodendrocyte lineage-specific basic helix-loop-helix (OLIG) family of transcription factors include OLIG1-OLIG3, which differ in tissue expression. OLIG1 and OLIG2 are specifically expressed in nervous tissue as gene regulators of oligodendrogenesis. OLIG2 is more widely expressed in embryonic brain than OLIG1, while OLIG3 is primarily expressed in non-neural tissues. OLIG1 and OLIG2 interact with the Nkx-2.2 homeodomain protein, which is responsible for directing ventral neuronal patterning in response to graded Sonic hedgehog signaling in the embryonic neural tube. These interactions between OLIG proteins and Nkx-2.2 appear to promote the formation of alternate cell types by inhibiting V3 interneuron development. OLIG1 and OLIG2 are abundantly expressed in oligodendroglioma and nearly absent in astrocytomas. Therefore, OLIG proteins are candidates for molecular markers of human glial brain tumors, which are the most common primary malignancies of the human brain.

Human, Mouse, Rat

Human,Mouse,Rat

-20°C,2°C to 8°C

41116161