Anti-OMA1 Mouse mAb

PTM BIO

Anti-OMA1 Mouse mAb

5

ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry Paraffin

WB, IHC-P, ICC/IF

Research Use Only

Monoclonal

JMMR-2720

Unconjugated

Mouse

IgG

Metalloendopeptidase OMA1, mitochondrial

Metalloendopeptidase OMA1 is an enzyme that is encoded by the OMA1 gene in human. OMA1 is a Zn2+-dependent metalloendopeptidase in the inner membrane of mitochondria. The OMA1 protease acts at the intersection of a mitochondrial quality control system and energy metabolism, whereby its activation correlates with outer membrane permeabilization and cytochrome c release in the context of apoptosis. Mammalian OMA1 can cleave the inner-membrane shaping protein OPA1 and the signaling peptide DELE1 in a context-dependent manner. Apoptotic stimuli, such as Bax and Bak, as well as other factors can trigger OMA1 activation and OPA1 processing, which are correlated with outer membrane permeabilization and cytochrome c release. The DELE1 protein is another OMA1 substrate, which is released upon cleavage into the cytosol, where it can activate the integrated stress response.

Stable for 12 months from date of receipt/reconstitution.

Human, Mouse, Rat

Human, Mouse, Rat

Protein A purified

Store at -20°C. Avoid freeze/thaw cycles.

12352203