Anti-OX40L [OX-89]

Absolute Antibody

Anti-OX40L [OX-89]

9

This antibody is specific for murine CD252 (the ligand for OX40), expression of which is restricted to activated B cells, dendritic cells, microglia and endothelial cells.

This antibody binds mouse CD134L, and has been shown to bind activated B cells and DCs, as well as CD134L-transfected fibroblast cells, though not activated T cells, in labelling and immunohistochemical analysis (Malmstrom, 2001). In addition, this antibody is able to partially block the interaction between CD134 and CD134L. This blocking effect could be responsible for the ability of this antibody to prevent T cell accumulation in the intestine of T cell-restored SCID mice and inhibits the development of Th1-mediated colitis.

Flow Cytometry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, Neutralisation/Blocking

Research Use Only

Monoclonal

OX-89

Tnfsf4

tumor necrosis factor (ligand) superfamily, member 4

Ath; Ath-; Ath1; Ath-1; atherosclerosis 1; CD134; CD134L; gp3; gp34; OX4; OX40 ligand; Ox40l; OX-40L; tax-transcriptionally activated glycoprotein 1 ligand; Tnlg2b; tumor necrosis factor ligand 2b; tumor necrosis factor ligand superfamily member 4; Txgp; TXGP1; Txgp1l

Rat

IgG1

Tumor necrosis factor ligand superfamily member 4

Mouse

-20°C,2°C to 8°C

12352203