Anti-Phospho-V-Myb+C-Myb (S11) Antibody [SZ04-81]

HUABIO

Anti-Phospho-V-Myb+C-Myb (S11) Antibody [SZ04-81]

7

ImmunoFluorescence, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

IF-Cell,IF-Tissue,IHC-P,FC

Research Use Only

Monoclonal

SZ04-81

1 mg/ml

Unconjugated

MYB

MYB proto-oncogene, transcription factor

Cmyb, c-myb, c-myb_CDS, efg, transcriptional activator Myb, MYB-GATA1 fusion protein, oncogene AMV, proto-oncogene c-Myb, v-myb avian myeloblastosis viral oncogene homolog

Rabbit

IgG

Transcriptional activator Myb

The Myb family of transcription factors regulates proliferation, differentiation and apoptosis of hematopoletic cells. The avian myeloblastosis viral (v-Myb) protein is nuclear and binds to specific DNA sequences. The gene encoding for v-Myb is oncogenic, causing monoblastic leukemia and transforming myelomonocytic cells by deregulating the expression of specific target genes. v-Myb functions as a transcriptional activator, and it can repress biologically relevant genes such as Ets-2, which promotes macrophage differentiation. The proto-oncogene c-Myb encodes for a nuclear protein that plays a role in transcriptional regulation and may be essential for hematopoietic cell proliferation. A-Myb is also member of the Myb family that is expressed in proliferating B cell centroblasts. Transgenic mice overexpressing A-Myb posses enhanced hyperplasia of the lymph nodes.

Human

Human

-20°C,2°C to 8°C

41116161