Anti-p47-phox Antibody [A6B10-R]

HUABIO

Anti-p47-phox Antibody [A6B10-R]

2

Western Blot

Research Use Only

Monoclonal

A6B10-R

1 mg/ml

Unconjugated

NCF1

neutrophil cytosolic factor 1

CGD1, NCF-1, NCF-47K, NCF1A, NOXO2, SH3PXD1A, p47-phox, p47phox, neutrophil cytosol factor 1, 47 kDa autosomal chronic granulomatous disease protein, 47 kDa neutrophil oxidase factor, NADPH oxidase organizer 2, SH3 and PX domain-containing protein 1A, neutrophil NADPH oxidase factor 1, neutrophil cytosolic factor 1, (chronic granulomatous disease, autosomal 1), nox organizer 2, nox-organizing protein 2

Mouse

IgG1

Neutrophil cytosol factor 1

The heredity chronic granulomatous disease (CGF) has been linked to mutations in p47phox and p67-phox. The cytosolic proteins p47phox and p67-phox, also designated neutrophil cytosol factor (NCF)1 and NCF2, respectively, are required for activation of the superoxide-producing NADPH oxidase in neutrophils and other phagocytic cells. During activation of the NADPH oxidase, p47phox and p67-phox migrate to the plasma membrane where they associate with cytochrome b558 and the small G protein Rac to form the functional enzyme complex. Both p47phox and p67-phox contain two Src homology 3 (SH3) domains. The C-terminal SH3 domain of p67-phox has been shown to interact with the proline-rich domain of p47phox, suggesting that p47phox may faciliate the transport of p67-phox to the membrane.

-20°C,2°C to 8°C

41116161