Anti-p53 Antibody [C8-A11]

HUABIO

Anti-p53 Antibody [C8-A11]

7

ImmunoFluorescence, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

WB,IF-Cell,IHC-P

Research Use Only

Monoclonal

C8-A11

2 mg/ml

Unconjugated

TP53

tumor protein p53

BCC7, BMFS5, LFS1, P53, TRP53, cellular tumor antigen p53, antigen NY-CO-13, mutant tumor protein 53, phosphoprotein p53, transformation-related protein 53, tumor protein 53, tumor supressor p53

Mouse

IgG1

Cellular tumor antigen p53

Cellular tumor antigen p53 is crucial in multicellular organisms, where it regulates the cell cycle and, thus, functions as a tumor suppressor, preventing cancer. As such, p53 has been described as the guardian of the genome because of its role in conserving stability by preventing genome mutation. Activated p53 binds DNA and activates expression of several genes including microRNA miR-34a, WAF1/CIP1 encoding for p21 and hundreds of other down-stream genes. p21 (WAF1) binds to the G1-S/CDK (CDK2) and S/CDK complexes (molecules important for the G1/S transition in the cell cycle) inhibiting their activity. p53 expression can be stimulated by UV light, which also causes DNA damage. In this case, p53 can initiate events leading to tanning.

Human

Human

-20°C,2°C to 8°C

41116161