Anti-Pan-Nav channel [K58/35]

Absolute Antibody

Anti-Pan-Nav channel [K58/35]

7

This pan-voltage-gated sodium channel antibody is specific for a conserved sequence present in all vertebrate Nav1 isoforms. It binds to all voltage-gated sodium channel isoforms.

This antibody has been used to stain teased axons prepared from rat spinal nerves (Devaux, 2012), sections of rat retina (Wart et al, 2005) and mice optic nerve cryosections (Vega et al, 2008) for Nav expression. This antibody has been shown to label Nav channels concentrated on the axon initial segment and nodes of Ranvier (Andrews et al, 2019). This antibody has been used in immunoblot analysis of rat brain membranes (Wart et al, 2005; Vega et al, 2013), and to stain COS-1 cells transfected with Nav1 cDNA (Wart et al, 2005). Additionally, this antibody has been used in western blot analysis of mice optic nerve and brain membrane proteins (Vega et al, 2008).

Western Blot, ImmunoHistoChemistry

IB; WB; IHC

Research Use Only

Monoclonal

K58/35

Rat

IgG2b

This chimeric rat antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.

Vertebrate

Vertebrates

This antibody was raised by immunising mice with a synthetic peptide corresponding to a highly conserved segment of the intracellular III–IV loop of vertebrate Na+ channels.

-20°C,2°C to 8°C

12352203