Anti-Pancreatic alpha-amylase [AMD9]

Absolute Antibody

Anti-Pancreatic alpha-amylase [AMD9]

7

This antibody binds the active site crevice of the porcine pancreatic alpha-amylase and is a strong amylase inhibitor.

This antibody can bind porcine pancreatic alpha-amylase in an ELISA and inibits the enzyme with an IC50 = 10nM (PMID: 9649422). This antibody interacts with the amino acid residues in the alpha amylase catalytic site and has a strong inhibitary action on the catalytic activity of the enzyme. The inhibitory interaction of AMD9 involved mainly its complementarity-determining region (CDR) 2 loop, whereas the CDR3 loop was small and certainly did not protrude (PMID: 11960990).

ELISA

ELISA

Research Use Only

Monoclonal

AMD9

AMY2

amylase, alpha 2B (pancreatic)

1,4-alpha-D-glucan glucanohydrolase; alpha-amylase; AMY2B; PA; pancreatic alpha-amylase

Rabbit

IgG

Pancreatic alpha-amylase

This chimeric rabbit antibody was made using the variable domain sequences of the original VHH format, for improved compatibility with existing reagents, assays and techniques.

Porcine

Pig (Sus scrofa)

The original antibody was generated by immunizing dromedary with the enzyme and isolating specific binders from the VHH cloned from peripheral blood lymphocytes.

-20°C,2°C to 8°C

12352203