Anti-PARK7/DJ1 Antibody [SN07-21]

HUABIO

Anti-PARK7/DJ1 Antibody [SN07-21]

7

Flow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

WB,IF-Cell,IF-Tissue,IHC-P,IP,FC

Research Use Only

Monoclonal

SN07-21

1 mg/ml

Unconjugated

PARK7

Parkinsonism associated deglycase

DJ-1, DJ1, GATD2, HEL-S-67p, Parkinson disease protein 7, Parkinson disease (autosomal recessive, early onset) 7, epididymis secretory sperm binding protein Li 67p, maillard deglycase, oncogene DJ1, parkinson protein 7, protein DJ-1, protein deglycase DJ-1, protein/nucleic acid deglycase DJ-1

Rabbit

IgG

Parkinson disease protein 7 homolog

PARK7/DJ1 is a ubiquitously expressed protein involved in various cellular processes including cell proliferation, RNA-binding, and oxidative stress. The protein has been found to colocalize within a subset of pathologic tau inclusions in a diverse group of neurodegenerative disorders known as tauopathies. Defects in PARK7/DJ1 are the cause of autosomal recessive early-onset Parkinsons disease 7 (PARK7). Parkinsons disease (PD) is a complex, multifactorial disorder that typically manifests after the age of 50 years. The disease is characterized by bradykinesia, resting tremor, muscular rigidity and postural instability. The pathology involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain. PARK7 is characterized by onset before 40 years and slow progression. It has also been suggested that PARK7/DJ1 is a mitogen dependent oncogene product involved in Ras related signal transduction pathways.

Human, Mouse

Human,Mouse

Rat

-20°C,2°C to 8°C

41116161