Anti-Parkin Antibody [JF82-09]

HUABIO

Anti-Parkin Antibody [JF82-09]

7

Flow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

WB,IF-Cell,IF-Tissue,IHC-P,IP,FC

Research Use Only

Monoclonal

JF82-09

1 mg/ml

Unconjugated

PRKN

parkin RBR E3 ubiquitin protein ligase

AR-JP, LPRS2, PARK2, PDJ, E3 ubiquitin-protein ligase parkin, Parkinson disease (autosomal recessive, juvenile) 2, parkin, parkinson juvenile disease protein 2, parkinson protein 2 E3 ubiquitin protein ligase, parkinson protein 2, E3 ubiquitin protein ligase (parkin)

Rabbit

IgG

E3 ubiquitin-protein ligase parkin

Parkin is a zinc-finger protein that is related to ubiquitin at the amino terminus. The wild type Parkin gene, which maps to human chromosome 6q25.2-27, encodes a 465 amino acid full-length protein that is expressed as multiple isoforms. Mutations in the Parkin gene are responsible for autosomal recessive juvenile Parkinsons disease and commonly involve deletions of exons 3-5. In humans, Parkin is expressed in a subset of cells of the basal ganglia, midbrain, cerebellum and cerebral cortex, and is subject to alternative splicing in different tissues. Parkin expression is also high in the brainstem of mice, with the majority of immunopositive cells being neurons. The Parkin gene has been identified in a diverse group of organisms including mammals, birds, frog and fruit flies, suggesting that analogous functional roles of the Parkin protein may have been highly conserved during the course of evolution.

Human, Mouse, Rat

Human,Mouse,Rat

-20°C,2°C to 8°C

41116161