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ProductsBack/anti-PARP-10 [ARTD10] (human), mAb (5H11)
Immunofluorescence using anti-PARP-10 [ARTD10] (human), mAb (5H11). Method: T47D mammary carcinoma cells were stained by indirect immunofluorescence and analysed. Prior to fixation and staining, the cells were treated with or without 50nm leptomyci
Immunofluorescence using anti-PARP-10 [ARTD10] (human), mAb (5H11). Method: T47D mammary carcinoma cells were stained by indirect immunofluorescence and analysed. Prior to fixation and staining, the cells were treated with or without 50nm leptomyci
Immunofluorescence using anti-PARP-10 [ARTD10] (human), mAb (5H11). Method: T47D mammary carcinoma cells were stained by indirect immunofluorescence and analysed. Prior to fixation and staining, the cells were treated with or without 50nm leptomyci

anti-PARP-10 [ARTD10] (human), mAb (5H11)

Research Use Only
AG-20T-0004
AdipoGen Life Sciences
ApplicationsImmunoPrecipitation, Western Blot, ImmunoCytoChemistry
DownloadMSDS
Product group Antibodies
ReactivityHuman
TargetPARP10
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    anti-PARP-10 [ARTD10] (human), mAb (5H11)
  • Delivery Days Customer
    10
  • Antibody Specificity
    Recognizes human PARP-10 [ARTD10] with an epitope between aa 256-407, containing the glycine rich (G-rich) region.
  • Applications
    ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    5H11
  • Gene ID84875
  • Target name
    PARP10
  • Target description
    poly(ADP-ribose) polymerase family member 10
  • Target synonyms
    ADP-ribosyltransferase diphtheria toxin-like 10; ARTD10; poly [ADP-ribose] polymerase 10; protein mono-ADP-ribosyltransferase PARP10
  • Host
    Rat
  • Isotype
    IgG1
  • Scientific Description
    Monoclonal Antibody. Recognizes human PARP-10 [ARTD10] with an epitope between aa 256-407, containing the glycine rich (G-rich) region. Isotype: Rat IgG1. Clone: 5H11. Applications: ICC, IP, WB. Liquid. Cell culture supernatant containing RPMI, 10% FCS and 0.05% sodium azide. PARP-10 is a mono-ADP-ribosyltransferase and was initially identified as an interaction partner of the proto-oncoprotein Myc. PARP-10 possesses ubiquitin-interaction motifs, which are important to inhibit the activation of NF-kappaB and downstream target genes in response to interleukin-1beta and tumor necrosis factor-alpha. PARP-10 mono(ADP-ribosyl)ates (MARylates) NEMO (NF-kappaB essential modulator), which results in reduced NEMO polyubiquitylation and thus decreased NF-kappaB signaling. Overexpression of PARP-10 was shown to lead to apoptosis. PARP-10 knockdown leads to increased cell survival. Additional substrates of PARP-10, such as GSK-3beta were identified and PARP-10-mediated mono(ADP-ribosyl)ation (MARylation) was shown to be involved in regulating multiple processes, including Wnt signaling. - PARP-10 [ARTD10] is a mono-ADP-ribosyltransferase and was initially identified as an interaction partner of the proto-oncoprotein Myc. PARP-10 possesses ubiquitin-interaction motifs, which are important to inhibit the activation of NF-kappaB and downstream target genes in response to interleukin-1beta [IL-1beta] and tumor necrosis factor-alpha [TNF-alpha]. PARP-10 mono(ADP-ribosyl)ates (MARylates) NEMO (NF-kappaB essential modulator), which results in reduced NEMO polyubiquitylation and thus decreased NF-kappaB signaling. Overexpression of PARP-10 was shown to lead to apoptosis. PARP-10 knockdown leads to increased cell survival. Additional substrates of PARP-10, such as GSK-3beta were identified and PARP-10-mediated mono(ADP-ribosyl)ation (MARylation) was shown to be involved in regulating multiple processes, including Wnt signaling.
  • Reactivity
    Human
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352203