Immunohistochemical staining of formalin fixed and paraffin embedded human tonsil tissue section using anti-PD-1 rabbit monoclonal antibody (Clone RM309) at a 1:500 dilution.
Immunohistochemical staining of formalin fixed and paraffin embedded human tonsil tissue section using anti-PD-1 rabbit monoclonal antibody (Clone RM309) at a 1:500 dilution.
anti-PD-1 (human), Rabbit Monoclonal (RM309)
REV-31-1195-00
ApplicationsWestern Blot, ImmunoHistoChemistry
Product group Antibodies
ReactivityHuman
TargetPDCD1
Overview
- SupplierRevMAb Biosciences
- Product Nameanti-PD-1 (human), Rabbit Monoclonal (RM309)
- Delivery Days Customer5
- ApplicationsWestern Blot, ImmunoHistoChemistry
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDRM309
- Gene ID5133
- Target namePDCD1
- Target descriptionprogrammed cell death 1
- Target synonymsCD279; hPD-1; hPD-l; hSLE1; PD1; PD-1; programmed cell death 1 protein; programmed cell death protein 1; protein PD-1; SLEB2; systemic lupus erythematosus susceptibility 2
- HostRabbit
- IsotypeIgG
- Scientific DescriptionProgrammed Death 1 (PD-1) is a member of the CD28/CTLA-4 family of T cell regulators, expressed as a co-receptor on the surface of activated T cells, B cells and macrophages. Several studies have suggested that the PD-1/PD-L1 signaling pathway may be linked to antitumor immunity, as PD-L1 has been shown to induce apoptosis of activated T cells or inhibit activity of cytotoxic T cells. In comparison to CD10 and Bcl-6, PD-1 is expressed by fewer B cells and has therefore been considered a more specific and useful diagnostic marker for angioimmunoblastic T cell lymphoma. Therapies targeted toward the PD-1 receptor have shown remarkable clinical responses in patients with various types of cancer, including non-small-cell lung cancer, melanoma and renal-cell cancer. - Recombinant Antibody. This antibody reacts to human PD-1 (Programmed cell death protein 1) (CD279). Applications: WB, IHC. Source: Rabbit. Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. Programmed Death 1 (PD-1) is a member of the CD28/CTLA-4 family of T cell regulators, expressed as a co-receptor on the surface of activated T cells, B cells and macrophages. Several studies have suggested that the PD-1/PD-L1 signaling pathway may be linked to antitumor immunity, as PD-L1 has been shown to induce apoptosis of activated T cells or inhibit activity of cytotoxic T cells. In comparison to CD10 and Bcl-6, PD-1 is expressed by fewer B cells and has therefore been considered a more specific and useful diagnostic marker for angioimmunoblastic T cell lymphoma. Therapies targeted toward the PD-1 receptor have shown remarkable clinical responses in patients with various types of cancer, including non-small-cell lung cancer, melanoma and renal-cell cancer.
- ReactivityHuman
- Storage Instruction-20°C
- UNSPSC12352203