Anti-PDCD4 Antibody [JA80-83]

HUABIO

Anti-PDCD4 Antibody [JA80-83]

7

ImmunoFluorescence, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

WB,IF-Cell,IHC-P,FC

Research Use Only

Monoclonal

JA80-83

1 mg/ml

Unconjugated

Pdcd4

programmed cell death 4

D19Ucla1, Ma3, Tis, programmed cell death protein 4, protein MA-3, topoisomerase-inhibitor suppressed protein

Rabbit

IgG

Programmed cell death protein 4

The transformation suppressor gene Pdcd-4 (programmed cell death gene 4) inhibits the tumor-promoter mediated transformation of mouse keratinocytes and is a potential tumor suppressor gene in the development of human lung cancer. Biochemical analysis suggests that the Pdcd-4 protein is involved in protein translation as well as in nuclear events. Pdcd-4 directly interacts with the RNA helicase eIF4A and inhibits protein synthesis by interfering with the assembly of the cap-dependent translation initiation complex. Pdcd-4 also suppresses the transactivation of AP-1 responsive promoters by c-Jun, suggesting that the transformation-suppressor activity of Pdcd-4 might be due, at least in part, to the inhibition of c-Jun activity. In addition to affecting c-Jun phosphorylation, Pdcd-4 blocks the recruitment of the co-activator p300 by c-Jun.

Human, Mouse

Human,Mouse

-20°C,2°C to 8°C

41116161