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Anti-PDCD4 Mouse mAb

PTM-6482
PTM BIO
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman
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Overview

  • Supplier
    PTM BIO
  • Product Name
    Anti-PDCD4 Mouse mAb
  • Delivery Days Customer
    5
  • Applications
    ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry Paraffin
  • Applications Supplier
    WB, IHC-P, ICC/IF
  • Category Supplier
    Antibody
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    JMMR-1367
  • Conjugate
    Unconjugated
  • Host
    Mouse
  • Isotype
    IgG
  • Protein IDQ53EL6
  • Protein Name
    Programmed cell death protein 4
  • Scientific Description
    PDCD4 was a suppressor of neoplastic transformation. It interacts with eukaryotic initiation factors eIF4AI and eIF4AII. PDCD4 colocalizes with eIF4A in the cytoplasm and inhibits the activity of eIF4A as an ATP-dependent RNA helicase. PDCD4 inhibits cap-dependent translation. Upon stimulation by mitogens, PDCD4 is Phosphorylatedrylated on Ser67 by S6K1 kinase and then degraded through the ubiquitin pathway leading to enhanced translation and cell growth.
  • Shelf life instruction
    Stable for 12 months from date of receipt/reconstitution.
  • Reactivity
    Human
  • Reactivity Supplier
    Human
  • Reactivity Supplier Note
    Protein A purified
  • Storage Instruction
    Store at -20°C. Avoid freeze/thaw cycles.
  • UNSPSC
    12352203