Anti-PDGFR beta Antibody [SY10-08]

HUABIO

Anti-PDGFR beta Antibody [SY10-08]

7

Flow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin, Other Application

WB,IHC-P,IP

Research Use Only

Monoclonal

SY10-08

1 mg/ml

Unconjugated

PDGFRB

platelet derived growth factor receptor beta

CD140B, IBGC4, IMF1, JTK12, KOGS, OPDKD, PDGFR, PDGFR-1, PDGFR1, PENTT, platelet-derived growth factor receptor beta, Activated tyrosine kinase PDGFRB, CD140 antigen-like family member B, NDEL1-PDGFRB, PDGF-R-beta, PDGFR-beta, beta-type platelet-derived growth factor receptor, platelet-derived growth factor receptor 1, platelet-derived growth factor receptor, beta polypeptide

Rabbit

IgG

Platelet-derived growth factor receptor beta

Platelet-derived growth factor (PDGF) is a mitogen for mesenchyme- and glia-derived cells. PDGF consists of two chains, A and B, which dimerize to form functionally distinct isoforms, PGDF-AA, PDGF-AB and PDGF-BB. These three isoforms bind with different affinities to two receptor types, PDGFR-alpha and -beta, which are endowed with protein tyrosine kinase domains. PDGFR-alpha can bind to both A and B subunits of PDGF, while PDGFR-beta can only bind the B subunit. Ligand binding promotes either homo- or heterodimerization of the PDGF receptors in a specific manner. PDGF-AA induces the dimerization of two alpha receptors, PDGF-AB induces dimerization of alphaalpha and alphabeta and PDGF-BB induces the formation of three types of dimers, alphaalpha, alphabeta and betabeta. Translocation of the PDGFR- gene with the Tel gene is linked to chronic myelomonocytic leukemia (CMML), a myelodysplastic syndrome, and demonstrates the oncogenic potential of the PDGF receptors.

Human, Mouse, Rat

Human,Mouse,Rat

-20°C,2°C to 8°C

41116161