Anti-PDHA1 Antibody [JF996-0]

HUABIO

Anti-PDHA1 Antibody [JF996-0]

7

Flow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

WB,IF-Cell,IF-Tissue,IHC-P,IP,FC

Research Use Only

Monoclonal

JF996-0

1 mg/ml

Unconjugated

PDHA1

pyruvate dehydrogenase E1 subunit alpha 1

E1alpha, PDHA, PDHAD, PDHCE1A, PHE1A, pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial, PDHE1-A type I, pyruvate dehydrogenase (lipoamide) alpha 1, pyruvate dehydrogenase E1 alpha 1 subunit, pyruvate dehydrogenase alpha 1, pyruvate dehydrogenase complex, E1-alpha polypeptide 1

Rabbit

IgG

Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial matrix enzyme complex that functions as the primary link between glycolysis and the tricarboxylic acid (TCA) cycle by catalyzing the irreversible conversion of pyruvate into acetyl-CoA. The E1 enzyme of the PDH complex is made up of a heterotetramer of two alpha and two beta subunits. The E1-alpha subunit (PDH-E1alpha) contains the E1 active site and plays a key role in the function of the PDH complex. The PDH complex is regulated by phosphorylation and dephosphorylation of PDH-E1alpha. The gene encoding for PDH-E1alpha maps to chromosome Xp22.12, and a 20bp deletion in the last exon of this gene is sufficient to cause PDH deficiency, which causes a broad range of symptoms including the development of seizures, mental retardation and spasticity, as well as intermittent episodes of lactic acidosis associated with cerebellar ataxia.

Human, Mouse, Rat

Human,Mouse,Rat

-20°C,2°C to 8°C

41116161