Anti-PDIA2 Antibody [JF97-08]

HUABIO

Anti-PDIA2 Antibody [JF97-08]

7

Western Blot

WB,FC

Research Use Only

Monoclonal

JF97-08

1 mg/ml

Unconjugated

PDIA2

protein disulfide isomerase family A member 2

PDA2, PDI, PDIP, PDIR, protein disulfide-isomerase A2, Rho GDP dissociation inhibitor gamma, pancreas-specific protein disulfide isomerase, pancreatic protein disulfide isomerase, protein disulfide isomerase, pancreatic, protein disulfide isomerase-associated 2

Rabbit

IgG

Protein disulfide-isomerase A2

Oxidoreductase-protein disulfide isomerase (PDI) is a homodimer consisting of subunits that catalyzes thiol-disulfide exchange, mediates folding of newly synthesized proteins and functions as a molecular chaperone. PDI localizes to the lumen of the endoplasmic reticulum (ER), where in conjunction with folding-helper proteins, such as immunoglobulin heavy chain binding protein (BiP), mediates tertiary and quaternary protein-processing. Cell surface PDI induces sulfhydryl-mediated conformational changes in integrin-mediated adhesion receptor-ligand interactions, thereby regulating integrin responses and cell adhesion. Additionally, PDI functions as a subunit of two more complex enzyme systems: the prolyl-4-hydroxylase and the triacylglycerol transfer proteins.

Human, Mouse, Rat

Human,Mouse,Rat

-20°C,2°C to 8°C

41116161