Anti-PDIA6 Antibody [JF0974]

HUABIO

Anti-PDIA6 Antibody [JF0974]

7

Flow Cytometry, ImmunoFluorescence, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

WB,IF-Cell,IF-Tissue,FC

Research Use Only

Monoclonal

JF0974

1 mg/ml

Unconjugated

PDIA6

protein disulfide isomerase family A member 6

ERP5, P5, TXNDC7, protein disulfide-isomerase A6, ER protein 5, endoplasmic reticulum protein 5, epididymis secretory sperm binding protein, protein disulfide isomerase P5, protein disulfide isomerase-associated 6, protein disulfide isomerase-related protein, thioredoxin domain containing 7 (protein disulfide isomerase), thioredoxin domain-containing protein 7

Rabbit

IgG

Protein disulfide-isomerase A6

Endoplasmic reticulum proteins (ERps) are widely expressed proteins that localize to the ER and may act as proteases, protein disulfide isomerases, thiol-disulfide oxidases or phospholipases. ERp5, also known as PDIA6 (protein disulfide isomerase family A, member 6) or TXNDC7 is a 440 amino acid protein that contains two thioredoxin domains and belongs to the protein disulfide isomerase family. Localized to the melanosome, as well as to the lumen of the endoplasmic reticulum, ERp5 functions to catalyze the rearrangement of disulfide bonds in a variety of different proteins. Via its catalytic activity, ERp5 is able to reduce the disulfide bond that binds MICA to tumor cells, thereby releasing MICA and reducing the rate of tumor expansion. Multiple isoforms of ERp5 exist due to alternative splicing events.

Human, Mouse

Human,Mouse

Rat

-20°C,2°C to 8°C

41116161