Anti-Periostin Antibody [JA63-40]

HUABIO

Anti-Periostin Antibody [JA63-40]

7

Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

WB,FC,IHC-P

Research Use Only

Monoclonal

JA63-40

1 mg/ml

Unconjugated

POSTN

periostin

OSF-2, OSF2, PDLPOSTN, PN, periostin, osteoblast specific factor 2 (fasciclin I-like), periodontal ligament-specific periostin, periostin, osteoblast specific factor

Rabbit

IgG

Periostin

Periostin (PN), also designated osteoblast-specific factor 2 (OSF-2), is a disulfide linked protein originally isolated as a osteoblast-specific factor. Periostin is a secreted protein that binds heparin and functions as a ligand for alpha(V)beta and alpha(V)beta integrins. In preosteoblasts, Periostin acts as a cell adhesion molecule and plays a role in osteoblast recruitment, spreading and attachment. Periostin is mainly detected in lower gastrointestinal tract, aorta, stomach, placenta, uterus and breast tissues but is up-regulated in epithelial ovarian tumors and overexpressed in breast cancer. Expression of Periostin is increased by bone morphogenetic protein (BMP2) and transforming growth factor beta 1(TGF beta 1). Periostin contains a typical signal sequence, followed by a cysteine-rich domain, a fourfold repeated domain, which shows homology with the insect protein fasciclin, and a C-terminal domain.

Human

Human

-20°C,2°C to 8°C

41116161