Anti-PGC1 alpha+beta Antibody [JF09-71]

HUABIO

Anti-PGC1 alpha+beta Antibody [JF09-71]

7

Western Blot

WB

Research Use Only

Monoclonal

JF09-71

1 mg/ml

Unconjugated

PPARGC1A

PPARG coactivator 1 alpha

LEM6, PGC-1(alpha), PGC-1alpha, PGC-1v, PGC1, PGC1A, PPARGC1, peroxisome proliferator-activated receptor gamma coactivator 1-alpha, L-PGC-1alpha, PGC-1-alpha, PPAR gamma coactivator variant form, PPARAGCIalpha, PPARGC-1-alpha, PPARgamma coactivator 1alpha, ligand effect modulator-6

Rabbit

IgG

Peroxisome proliferator-activated receptor gamma coactivator 1-alpha

Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1alpha) is a protein that in humans is encoded by the PPARGC1A gene. PPARGC1A is also known as human accelerated region 20 (HAR20). It may, therefore, have played a key role in differentiating humans from apes. PGC-1alpha is the master regulator of mitochondrial biogenesis. PGC-1alpha is also the primary regulator of liver gluconeogenesis, inducing increased gene expression for gluconeogeneis. PGC-1alpha is a transcriptional coactivator that regulates the genes involved in energy metabolism. Peroxisome proliferator-activated receptor gamma coactivator 1-beta is a protein that in humans is encoded by the PPARGC1B gene. The protein encoded by this gene stimulates the activity of several transcription factors and nuclear receptors, including estrogen receptor alpha, nuclear respiratory factor 1, and glucocorticoid receptor. The encoded protein may be involved in fat oxidation, non-oxidative glucose metabolism, and the regulation of energy expenditure. This protein is downregulated in prediabetic and type 2 diabetes mellitus patients. Certain allelic variations in this gene increase the risk of the development of obesity.

Mouse

Mouse

Human,Rat

-20°C,2°C to 8°C

41116161