Anti-Phospho-AMPK alpha 2 (S345) Antibody [JJ08-19]

HUABIO

Anti-Phospho-AMPK alpha 2 (S345) Antibody [JJ08-19]

7

Flow Cytometry, ImmunoFluorescence, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

WB,IF-Cell,IF-Tissue,IHC-P

Research Use Only

Monoclonal

JJ08-19

1 mg/ml

Unconjugated

PRKAA2

protein kinase AMP-activated catalytic subunit alpha 2

AMPK, AMPK2, AMPKa2, PRKAA, 5'-AMP-activated protein kinase catalytic subunit alpha-2, 5'-AMP-activated protein kinase, catalytic alpha-2 chain, ACACA kinase, AMPK alpha 2, AMPK subunit alpha-2, AMPK-alpha-2 chain, HMGCR kinase, acetyl-CoA carboxylase kinase, hydroxymethylglutaryl-CoA reductase kinase, protein kinase, AMP-activated, alpha 2 catalytic subunit

Rabbit

IgG

5'-AMP-activated protein kinase catalytic subunit alpha-2

Five-prime-AMP-activated protein kinase, known as AMPK, is a heterotrimeric complex that comprises of a catalytic alpha subunit, and regulatory beta and gamma. AMPK protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. AMPK is activated by high AMP and low ATP via a mechanism involving allosteric regulation, promotion of phosphorylation by an upstream protein kinase known as AMPK kinase (AMPKK), and inhibition of dephosphorylation. Activated AMPK can phosphorylate and regulate in vivo hydroxymethylglutaryl-CoA reductase and acetyl-CoA carboxylase, which are key regulatory enzymes of sterol synthesis and fatty acid synthesis, respectively. The human AMPKalpha1 gene maps to chromosome 5p12 and encodes a 548 amino acid protein.

Human, Mouse

Human,Mouse

Rat

-20°C,2°C to 8°C

41116161