Anti-Phospho-ATR (T1989) Antibody [PS01-18]
HA721190
ApplicationsImmunoFluorescence, Western Blot
Product group Antibodies
TargetATR
Overview
- SupplierHUABIO
- Product NameAnti-Phospho-ATR (T1989) Antibody [PS01-18]
- Delivery Days Customer2
- ApplicationsImmunoFluorescence, Western Blot
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDPS01-18
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID545
- Target nameATR
- Target descriptionATR checkpoint kinase
- Target synonymsFCTCS, FRP1, MEC1, SCKL, SCKL1, serine/threonine-protein kinase ATR, ATR serine/threonine kinase, FRAP-related protein-1, MEC1, mitosis entry checkpoint 1, homolog, ataxia telangiectasia and Rad3-related protein
- HostRabbit
- IsotypeIgG
- Protein IDQ13535
- Protein NameSerine/threonine-protein kinase ATR
- Scientific DescriptionSerine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. Phosphorylates Ser-139 of histone variant H2AX at sites of DNA damage, thereby regulating DNA damage response mechanism. Required for FANCD2 ubiquitination. Critical for maintenance of fragile site stability and efficient regulation of centrosome duplication. Positively regulates the restart of stalled replication forks following activation by the KHDC3L-OOEP scaffold complex.
- Storage Instruction-20°C,2°C to 8°C
- UNSPSC41116161