Anti-Phospho-BTK (Y223) Antibody [ST51-05]

HUABIO

Anti-Phospho-BTK (Y223) Antibody [ST51-05]

7

ImmunoPrecipitation, Western Blot

WB,IP

Research Use Only

Monoclonal

ST51-05

1 mg/ml

Unconjugated

BTK

Bruton tyrosine kinase

AGMX1, AT, ATK, BPK, IGHD3, IMD1, PSCTK1, XLA, tyrosine-protein kinase BTK, B-cell progenitor kinase, Bruton agammaglobulinemia tyrosine kinase, Bruton's tyrosine kinase, agammaglobulinaemia tyrosine kinase, dominant-negative kinase-deficient Brutons tyrosine kinase

Rabbit

IgG

Tyrosine-protein kinase BTK

The Tec family of non-receptor tyrosine kinases is composed of six proteins designated Tec, Emt (also known as Itk or Tsk), Btk (previously known as Atk, BPK or Emb), Bmx, Txk (also known as Rlk) and Dsrc28C. All members of the family contain SH3 and SH2 domains and, with the exception of Txk and Dsrc28C, also contain a pleckstrin homology (PH) and a Tec homology (TH) domain in their amino termini. Four alternatively spliced forms of Tec are found to be expressed broadly in cells of hematopoietic lineage and hepatocytes. The Emt gene product associates with CD28 and becomes activated subsequent to CD28 ligation. Btk is necessary for proper B cell development, and mutations in the gene encoding Btk have been associated with families suffering from X-linked agammaglobulinemia, also referred to as Brutons disease. The Bmx protein shares a high degree of homology with Btk and seems to be expressed at highest levels in the heart. Txk expression is T cell-specific, while expression of the Drosophila Tec homolog, Dsrc28C, is developmentally regulated.

Human

Human

-20°C,2°C to 8°C

41116161