Anti-Phospho-CDC37 (S13) Antibody [SD08-50]

HUABIO

Anti-Phospho-CDC37 (S13) Antibody [SD08-50]

7

ImmunoPrecipitation, Western Blot

WB,IP

Research Use Only

Monoclonal

SD08-50

1 mg/ml

Unconjugated

CDC37

cell division cycle 37, HSP90 cochaperone

P50CDC37, hsp90 co-chaperone Cdc37, CDC37 (cell division cycle 37, S. cerevisiae, homolog), CDC37 cell division cycle 37 homolog, cell division cycle 37 homolog, hsp90 chaperone protein kinase-targeting subunit

Rabbit

IgG

Hsp90 co-chaperone Cdc37

Cell cycle events are regulated by the sequential activation and deactivation of cyclin dependent kinases (Cdks) and by the proteolysis of cyclins. The cell division cycle (Cdc) genes are required at various points in the cell cycle. Cdc25A, Cdc25B and Cdc25C protein tyrosine phosphatases function as mitotic activators by dephosphorylating Cdc2 p34 on regulatory tyrosine residues. Cdc6 is the human homolog of Saccharomyces cerevisiae Cdc6, which is involved in the initiation of DNA replication. Cdc37 appears to facilitate Cdk4/cyclin D1 complex formation and has been shown to form a stable complex with Hsp90. Cdc34, Cdc27 and Cdc16 function as ubiquitin-conjugating enzymes. Cdc34 is thought to be the structural and functional homolog of Saccharomyces cerevisiae Cdc34, which is essential for the G1 to S phase transition. Cdc16 and Cdc27 are components of the APC (anaphase-promoting complex) which ubiquitinates cyclin B, resulting in cyclin B/Cdk complex degradation.

Human, Mouse

Human,Mouse

Rat

-20°C,2°C to 8°C

41116161