Anti-Phospho-PKC alpha (T638) Antibody [JF0964]

HUABIO

Anti-Phospho-PKC alpha (T638) Antibody [JF0964]

7

ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

WB,IF-Cell,IF-Tissue,IHC-P,IP

Research Use Only

Monoclonal

JF0964

1 mg/ml

Unconjugated

PRKCA

protein kinase C alpha

AAG6, PKC-alpha, PKCA, PKCI+/-, PKCalpha, PRKACA, protein kinase C alpha type, PKC-A, aging-associated gene 6

Rabbit

IgG

Protein kinase C alpha type

Members of the protein kinase C (PKC) family play a key regulatory role in a variety of cellular functions including cell growth and differentiation, gene expression, hormone secretion and membrane function. PKCs were originally identified as serine/threonine protein kinases whose activity was dependent on calcium and phospholipids. Diacylglycerols (DAG) and tumor-promoting phorbol esters bind to and activate PKC. PKCs can be subdivided into many different isoforms (alpha, betaI, betaII, gamma, delta, epsilon, aeta, eta, theta, lambda/iota, micro and nu). Patterns of expression for each PKC isoform differ among tissues and PKC family members exhibit clear differences in their cofactor dependencies. For instance, the kinase activities of PKC delta and epsilon are independent of Ca2+. On the other hand, most of the other PKC members possess phorbol ester-binding activities and kinase activities.

Human, Mouse, Rat

Human,Mouse,Rat

-20°C,2°C to 8°C

41116161