Anti-Phospho-Raf1 (S43) Antibody [SD087-05]

HUABIO

Anti-Phospho-Raf1 (S43) Antibody [SD087-05]

7

Western Blot

WB

Research Use Only

Monoclonal

SD087-05

1 mg/ml

Unconjugated

RAF1

Raf-1 proto-oncogene, serine/threonine kinase

CMD1NN, CRAF, NS5, Raf-1, c-Raf, RAF proto-oncogene serine/threonine-protein kinase, C-Raf proto-oncogene, serine/threonine kinase, Oncogene RAF1, proto-oncogene c-RAF, raf proto-oncogene serine/threonine protein kinase, v-raf-1 murine leukemia viral oncogene homolog 1, v-raf-1 murine leukemia viral oncogene-like protein 1

Rabbit

IgG

RAF proto-oncogene serine/threonine-protein kinase

Several serine/threonine protein kinases have been implicated as intermediates in signal transduction pathways. These include ERK/MAP kinases, ribosomal S6 kinase (Rsk)and Raf-1. Raf-1 is a cytoplasmic protein with intrinsic serine/threonine activity. It is broadly expressed in nearly all cell lines tested to date and is the cellular homolog of v-Raf, the product of the transforming gene of the 3611 strain of murine sarcoma virus. The unregulated kinase activity of the v-Raf protein has been associated with transformation and mitogenesis while the activity of Raf-1 is normally suppressed by a regulatory N-terminal domain. Raf-1 is activated in response to activation of a variety of tyrosine kinase receptors as well as in response to pp60v-Src expression. There is accumulating evidence that Ras p21 may play a role in activation of Raf-1 and may play the role of the messenger from membrane tyrosine kinases to Raf-1.

Human, Mouse

Human,Mouse

Rat

-20°C,2°C to 8°C

41116161