Anti-Phospho-Src (Y419) Antibody [ST0800]

HUABIO

Anti-Phospho-Src (Y419) Antibody [ST0800]

7

Flow Cytometry, ImmunoFluorescence, Western Blot

WB,FC

Research Use Only

Monoclonal

ST0800

1 mg/ml

Unconjugated

SRC

SRC proto-oncogene, non-receptor tyrosine kinase

ASV, SRC1, THC6, c-SRC, p60-Src, proto-oncogene tyrosine-protein kinase Src, proto-oncogene c-Src, protooncogene SRC, Rous sarcoma, tyrosine kinase pp60c-src, tyrosine-protein kinase SRC-1, v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog

Rabbit

IgG

Proto-oncogene tyrosine-protein kinase Src

The Src family of protein tyrosine kinases, which includes Src, Lyn, Fyn, Yes, Lck, Blk, and Hck, are important in the regulation of growth and differentiation of eukaryotic cells. Dephosphorylated at Tyr-530 by PTPRJ (By similarity). Phosphorylated on Tyr-530 by c-Src kinase (CSK). The phosphorylated form is termed pp60c-src. Dephosphorylated by PTPRJ at Tyr-419. Normally maintained in an inactive conformation with the SH2 domain engaged with Tyr-530, the SH3 domain engaged with the SH2-kinase linker, and Tyr-419 dephosphorylated. Dephosphorylation of Tyr-530 as a result of protein tyrosine phosphatase (PTP) action disrupts the intramolecular interaction between the SH2 domain and Tyr-530, Tyr-419 can then become autophosphorylated, resulting in SRC activation. Phosphorylation of Tyr-530 by CSK allows this interaction to reform, resulting in SRC inactivation. S-nitrosylation is important for activation of its kinase activity.

Human

Human

Mouse,Rat

-20°C,2°C to 8°C

41116161