Anti-Phospho-STAT5 (Y694) Antibody [SC05-31]

HUABIO

Anti-Phospho-STAT5 (Y694) Antibody [SC05-31]

7

ImmunoFluorescence, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

WB,IHC-P

Research Use Only

Monoclonal

SC05-31

1 mg/ml

Unconjugated

STAT5A

signal transducer and activator of transcription 5A

MGF, STAT5, signal transducer and activator of transcription 5A, epididymis secretory sperm binding protein

Rabbit

IgG

Signal transducer and activator of transcription 5A

Stat5 (Signal Transducers and Activators of Transcription 5) is important in regulating T cell functions involving the receptors for Interleukin-2 (IL-2). IL-2 stimulates the rapid phosphorylation of both serine and tyrosine residues of Stat5a and Stat5b in human T lymphocytes and in several IL-2-responsive lymphocytic cell lines. IL-2 differentially induces serine phosphorylation of Stat5a and Stat5b on Ser726 and Ser731, respectively. Stat5b is preferentially phosphorylated and displays more protracted serine phosphorylation kinetics than Stat5a. Both the acid-rich region and the COOH terminus of IL-2Rb can independently mediate IL-2-induced Stat 5a/b serine phosphorylation, suggesting that Stat5a/b serine phosphorylation occurs at a postreceptor level. Stat5a is phosphorylated on Tyr694 in a prolactin-sensitive manner, whereas serine phosphorylation is constitutive. Activation of Stat5 by IL-2 may help govern the biological effects of IL-2 during the immune response.

Human

Human

Mouse

-20°C,2°C to 8°C

41116161