Anti-Phosphorylated-FADD (Ser194) Rabbit mAb

PTM BIO

Anti-Phosphorylated-FADD (Ser194) Rabbit mAb

5

Western Blot

WB

Research Use Only

Monoclonal

JRMR-10749-71

Unconjugated

Rabbit

IgG

FAS-associated death domain protein

The protein is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade.

Stable for 12 months from date of receipt/reconstitution.

Human

Human

Protein A purified

Store at -20°C. Avoid freeze/thaw cycles.

12352203