Anti-Phosphorylated-p38 MAPK (Thr180/Tyr182) Rabbit mAb

PTM BIO

Anti-Phosphorylated-p38 MAPK (Thr180/Tyr182) Rabbit mAb

5

Western Blot

WB

Research Use Only

Monoclonal

JRMR-10996-33

Unconjugated

Rabbit

IgG

Mitogen-activated protein kinase 13

p38 MAP kinase (MAPK), also called RK or CSBP, is the mammalian orthologue of the yeast HOG kinase that participates in a signaling cascade controlling cellular responses to cytokines and stress. Four isoforms of p38 MAPK, p38alfa, bèta, gamma (also known as Erk6 or SAPK3), and delta (also known as SAPK4) have been identified. Similar to the SAPK/JNK pathway, p38 MAPK is activated by a variety of cellular stresses, including osmotic shock, inflammatory cytokines, lipopolysaccharide (LPS), UV light, and growth factors. MKK3, MKK6, and SEK activate p38 MAPK by Phosphorylatedrylation at Thr180 and Tyr182. Activated p38 MAPK has been shown to Phosphorylatedrylate and activate MAPKAP kinase 2 and to Phosphorylatedrylate the transcription factors ATF-2, Max, and MEF2. SB203580 is a selective inhibitor of p38 MAPK. This compound inhibits the activation of MAPKAPK-2 by p38 MAPK and subsequent Phosphorylatedrylation of HSP27. SB203580 inhibits p38 MAPK catalytic activity by binding to the ATP-binding pocket, but does not inhibit Phosphorylatedrylation of p38 MAPK by upstream kinases.

Stable for 12 months from date of receipt/reconstitution.

Human, Mouse, Rat

Human, Mouse, Rat

Protein A purified

Store at -20°C. Avoid freeze/thaw cycles.

12352203