Anti-Phosphorylated-SIRT1 (Ser27) Rabbit mAb

PTM BIO

Anti-Phosphorylated-SIRT1 (Ser27) Rabbit mAb

5

ImmunoFluorescence, Western Blot, ImmunoCytoChemistry

WB, ICC/IF

Research Use Only

Monoclonal

JMMR-2630B

Unconjugated

Rabbit

IgG

NAD-dependent protein deacetylase sirtuin-1

SIRT1 is a member of the Silent Information Regulator2 (SIR2) family, which is a highly conserved group of genes that encode nicotinamide adenine dinucleotide (NAD)-dependent protein deacetylases, also known as class III histone deacetylases. The first discovered and best characterized of these genes is Saccharomyces cerevisiae SIR2, which is involved in silencing of mating type loci, telomere maintenance, DNA damage response, and cell aging. SirT1, the mammalian ortholog of Sir2, is a nuclear protein implicated in the regulation of many cellular processes, including apoptosis, cellular senescence, endocrine signaling, glucose homeostasis, aging, and longevity. Targets of SirT1 include acetylated p53, p300, Ku70, forkhead (FoxO) transcription factors, PPARgamma, and the PPARgamma coactivator-1alfa (PGC-1alfa) protein. SirT1 deacetylase activity is inhibited by nicotinamide and activated by resveratrol. In addition, SirT1 activity may be regulated by Phosphorylatedrylation, as it is Phosphorylatedrylated at Ser27 and Ser47 in vivo; however, the function of these Phosphorylatedrylation sites has not yet been determined.

Stable for 12 months from date of receipt/reconstitution.

Human

Human

Protein A purified

Store at -20°C. Avoid freeze/thaw cycles.

12352203