Anti-Phosphorylated-SIRT1 (Ser47) Rabbit mAb

PTM BIO

Anti-Phosphorylated-SIRT1 (Ser47) Rabbit mAb

5

Western Blot, ImmunoHistoChemistry Paraffin

WB, IHC-P

Research Use Only

Monoclonal

JMMR-2631

Unconjugated

Rabbit

IgG

NAD-dependent protein deacetylase sirtuin-1

SIRT1, the mammalian ortholog of Sir2, is a nuclear protein implicated in the regulation of many cellular processes, including apoptosis, cellular senescence, endocrine signaling, glucose homeostasis, aging, and longevity. Targets of SirT1 include acetylated p53, p300, Ku70, forkhead (FoxO) transcription factors, PPARgamma, and the PPARgamma coactivator-1alfa (PGC-1alfa) protein. Deacetylation of p53 and FoxO transcription factors represses apoptosis and increases cell survival. Deacetylation of PPARgamma and PGC-1alfa regulates the gluconeogenic/glycolytic pathways in the liver and fat mobilization in white adipocytes in response to fasting. SirT1 deacetylase activity is inhibited by nicotinamide and activated by resveratrol. In addition, SirT1 activity may be regulated by Phosphorylatedrylation, as it is Phosphorylatedrylated at Ser27 and Ser47 in vivo; however, the function of these Phosphorylatedrylation sites has not yet been determined.

Stable for 12 months from date of receipt/reconstitution.

Human

Human

Protein A purified

Store at -20°C. Avoid freeze/thaw cycles.

12352203