Anti-Phosphorylated-YAP1 (Ser127) Rabbit mAb

PTM BIO

Anti-Phosphorylated-YAP1 (Ser127) Rabbit mAb

5

Flow Cytometry, ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry Paraffin

WB, IHC-P, ICC/IF, FC

Research Use Only

Monoclonal

PA-122-36

Unconjugated

Rabbit

IgG

Transcriptional coactivator YAP1

Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, Phosphorylatedrylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn Phosphorylatedrylates and inactivates YAP1 oncoprotein. Plays a key role to control cell proliferation in response to cell contact. Phosphorylatedrylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration.

Stable for 12 months from date of receipt/reconstitution.

Human

Protein A purified

Store at -20°C. Avoid freeze/thaw cycles.

12352203