Anti-VPS34 Antibody [SY0286]

HUABIO

Anti-VPS34 Antibody [SY0286]

7

Flow Cytometry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

WB,IHC-P,FC

Research Use Only

Monoclonal

SY0286

1 mg/ml

Unconjugated

PIK3C3

phosphatidylinositol 3-kinase catalytic subunit type 3

VPS34, Vps34, hVps34, phosphatidylinositol 3-kinase catalytic subunit type 3, PI3-kinase type 3, PI3K type 3, PtdIns-3-kinase type 3, phosphatidylinositol 3-kinase p100 subunit, phosphoinositide-3-kinase, class 3, vacuolar protein sorting 34 homolog

Rabbit

IgG

Phosphatidylinositol 3-kinase catalytic subunit type 3

Phosphatidylinositol 3-kinase catalytic subunit type 3 is an enzyme subunit that in humans is encoded by the PIK3C3 gene. Its a class III phosphoinositide 3-kinase. It is ubiquitously expressed with predominant expression in skeletal muscle and is believed to participate in endosome to lysosome transport, multivesicular body formation, autophagy and retrograde endosome to Golgi transport. PI 3-kinase p100 is the catalytic subunit of class III PI3Ks and forms a heterodimer with p150, a regulatory subunit of class 3 PI3Ks. PI 3-kinase p100 exclusively phosphorylates phosphatidylinositol to produce PtdIns3P. Unlike class I PI3Ks, whose activities are enhanced in the presence of magnesium, PI 3-kinase p100 activity is enhanced by manganese. Its activity can also be regulated by nutrients, suggesting an important role of PI-3 kinase p100 in the regulation of mTOR protein synthesis and autophagy.

Human, Mouse, Rat

Human,Mouse,Rat

-20°C,2°C to 8°C

41116161