Anti-PI 3 Kinase p85 alpha Antibody [SU04-07]

HUABIO

Anti-PI 3 Kinase p85 alpha Antibody [SU04-07]

7

Flow Cytometry, ImmunoFluorescence, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

WB,IF-Cell,IF-Tissue,IHC-P,FC

Research Use Only

Monoclonal

SU04-07

1 mg/ml

Unconjugated

PIK3R1

phosphoinositide-3-kinase regulatory subunit 1

AGM7, GRB1, IMD36, p85, p85-ALPHA, p85alpha, phosphatidylinositol 3-kinase regulatory subunit alpha, PI3 kinase-associated p85, PI3-kinase subunit p85-alpha, PI3K regulatory subunit alpha, growth factor receptor bound 1, phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha, phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha), phosphatidylinositol 3-kinase-associated p-85 alpha, phosphoinositide-3-kinase regulatory subunit alpha, phosphoinositide-3-kinase, regulatory subunit 1 (alpha), ptdIns-3-kinase regulatory subunit alpha

Rabbit

IgG

Phosphatidylinositol 3-kinase regulatory subunit alpha

Phosphatidylinositol 3-kinase (PI 3-kinase) phosphorylates the 3 OH position of the inositol ring of inositol lipids and is composed of p85 and p110 subunits. PI 3-kinase p85 lacks PI 3-kinase activity and acts as an adapter, coupling p110 to activated protein tyrosine kinase. Two forms of p85 have been described (p85alpha and p85beta), each possessing one SH3 and two SH2 domains. PI 3-kinase p85alpha, also known as GRB1, phosphatidylinositol 3-kinase regulatory 1 or p85, is a 724 amino acid protein that exists as four alternatively spliced isoforms. Involved in insulin metabolism, defects in the PI 3-kinase p85alpha gene have been linked to insulin resistance. PI 3-kinase p85alpha is polyubiquitinated in T-cells by Cbl-b, and has multiple phosphorylated amino acid residues, including a phosphorylated tyrosine residue at position 467.

Human, Mouse

Human,Mouse

Rat

-20°C,2°C to 8°C

41116161