Anti-PI 3 Kinase p85 beta Antibody [ST04-77]

HUABIO

Anti-PI 3 Kinase p85 beta Antibody [ST04-77]

7

Flow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

WB,IF-Cell,IF-Tissue,IHC-P,IP,FC

Research Use Only

Monoclonal

ST04-77

1 mg/ml

Unconjugated

PIK3R2

phosphoinositide-3-kinase regulatory subunit 2

MPPH, MPPH1, P85B, p85, p85-BETA, p85beta, phosphatidylinositol 3-kinase regulatory subunit beta, PI3-kinase subunit p85-beta, PI3K regulatory subunit beta, phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta, phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 2 (p85 beta), phosphoinositide-3-kinase regulatory subunit beta, phosphoinositide-3-kinase, regulatory subunit 2 (beta), ptdIns-3-kinase regulatory subunit p85-beta

Rabbit

IgG

Phosphatidylinositol 3-kinase regulatory subunit beta

Phosphatidylinositol 3-kinase (PI 3-kinase) is composed of p85 and p110 subunits. p85 lacks PI 3-kinase activity and acts as an adapter, coupling p110 to activated protein tyrosine kinase. Two forms of p85 have been described (p85alpha and p85beta), each possessing one SH3 and two SH2 domains. Various p110 isoforms have been identified. p110alpha and p110beta interact with p85alpha, and p110alpha has also been shown to interact with p85beta in vitro. p110alpha expression is restricted to white blood cells. It has been shown to bind p85alpha and p85beta, but it apparently does not phosphorylate these subunits. p110alpha seems to have the capacity to autophosphorylate. p110alpha does not interact with the p85 subunits. It has been shown to be activated by alpha and beta heterotrimeric G proteins.

Human, Rat

Human,Rat

-20°C,2°C to 8°C

41116161