Anti-PI3-kinase p110 subunit beta Antibody [SC0580]

HUABIO

Anti-PI3-kinase p110 subunit beta Antibody [SC0580]

7

Flow Cytometry, ImmunoPrecipitation, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

WB,IP,IHC-P,FC

Research Use Only

Monoclonal

SC0580

1 mg/ml

Unconjugated

PIK3CB

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta

P110BETA, PI3K, PI3KBETA, PIK3C1, phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform, PI3-kinase p110 subunit beta, PI3-kinase subunit beta, PI3K-beta, PtdIns-3-kinase p110, phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta, phosphoinositide-3-kinase, catalytic, beta polypeptide, ptdIns-3-kinase subunit beta, ptdIns-3-kinase subunit p110-beta, serine/threonine protein kinase PIK3CB

Rabbit

IgG

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform

Phosphatidylinositol 3-kinase (PI 3-kinase) is composed of p85 and p110 subunits. p85 lacks PI 3-kinase activity and acts as an adapter, coupling p110 to activated protein tyrosine kinase. Two forms of p85 have been described (p85alpha and p85beta), each possessing one SH3 and two SH2 domains. Various p110 isoforms have been identified. p110alpha and p110beta interact with p85alpha, and p110alpha has also been shown to interact with p85beta in vitro. p110 expression is restricted to white blood cells. It has been shown to bind p85alpha and beta, but it apparently does not phosphorylate these subunits. p110delta seems to have the capacity to autophosphorylate. p110gamma does not interact with the p85 subunits. It has been shown to be activated by alpha and beta gamma heterotrimeric G proteins.

Human

Human

-20°C,2°C to 8°C

41116161