Anti-PIAS1 Antibody [JE36-84]

HUABIO

Anti-PIAS1 Antibody [JE36-84]

2

Flow Cytometry, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Monoclonal

JE36-84

1 mg/ml

Unconjugated

PIAS1

protein inhibitor of activated STAT 1

DDXBP1, GBP, GU/RH-II, ZMIZ3, E3 SUMO-protein ligase PIAS1, AR interacting protein, DEAD/H (Asp-Glu-Ala-Asp/His) box binding protein 1, DEAD/H box-binding protein 1, E3 SUMO-protein transferase PIAS1, RNA helicase II-binding protein, gu-binding protein, protein inhibitor of activated STAT protein 1, zinc finger, MIZ-type containing 3

Rabbit

IgG

E3 SUMO-protein ligase PIAS1

Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. In vitro, binds A/T-rich DNA. The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context. Sumoylates PML (atLys-65 and Lys-160) and PML-RAR and promotes their ubiquitin-mediated degradation. PIAS1-mediated sumoylation of PML promotes its interaction with CSNK2A1/CK2 which in turn promotes PML phosphorylation and degradation. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation. Plays a dynamic role in adipogenesis by promoting the SUMOylation and degradation of CEBPB.

-20°C,2°C to 8°C

41116161