Anti-PRKAR2B (regulatory subunit) Antibody [JA11-69]

HUABIO

Anti-PRKAR2B (regulatory subunit) Antibody [JA11-69]

7

Flow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

WB,IP,IF-Cell,IF-Tissue,IHC-P,FC

Research Use Only

Monoclonal

JA11-69

1 mg/ml

Unconjugated

PRKAR2B

protein kinase cAMP-dependent type II regulatory subunit beta

PRKAR2, RII-BETA, cAMP-dependent protein kinase type II-beta regulatory subunit, H_RG363E19.2, WUGSC:H_RG363E19.2, cAMP-dependent protein kinase type II-beta regulatory chain, protein kinase, cAMP-dependent, regulatory subunit type II beta, protein kinase, cAMP-dependent, regulatory, type II, beta

Rabbit

IgG

cAMP-dependent protein kinase type II-beta regulatory subunit

The second messenger cyclic AMP mediates diverse cellular responses to external signals such as proliferation, ion transport, regulation of metabolism and gene transcription by activation of the cAMP-dependent protein kinase (cAPK or PKA). Activation of PKA occurs when cAMP binds to the two regulatory subunits of the tetrameric PKA holoenzyme resulting in release of active catalytic subunits. One of several regulatory subunits, p-PKA IIbeta reg (cAMP-dependent protein kinase type II-beta regulatory subunit), also known as PRKAR2B, is a 418 amino acid protein that is phosphorylated by the activated catalytic chain. p-PKA IIbeta reg knockout mice exhibit diminished white adipose tissue and were protected against diet-induced obesity and fatty livers,as well as markedly reduced leptin mRNA. Also playing a role in the immune response, p-PKA IIbeta reg suppresses CREB transcriptional activity and down-regulates IL-2 production in T-lymphocytes.

Human, Mouse, Rat

Human,Mouse,Rat

-20°C,2°C to 8°C

41116161