Anti-PKM2 Antibody

HUABIO

Anti-PKM2 Antibody

7

Flow Cytometry, ImmunoFluorescence, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

WB,IF-Cell,IHC-P,FC

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

PKM

pyruvate kinase M1/2

CTHBP, HEL-S-30, OIP3, PK3, PKM2, TCB, THBP1, p58, pyruvate kinase PKM, OPA-interacting protein 3, PK, muscle type, cytosolic thyroid hormone-binding protein, epididymis secretory protein Li 30, pyruvate kinase 2/3, pyruvate kinase isozymes M1/M2, pyruvate kinase muscle isozyme, pyruvate kinase, muscle, threonine-protein kinase PKM2, thyroid hormone-binding protein 1, thyroid hormone-binding protein, cytosolic, tumor M2-PK, tyrosine-protein kinase PKM2

Rabbit

IgG

Pyruvate kinase PKM

Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival . Promotes in a STAT1-dependent manner, the expression of the immune checkpoint protein CD274 in ARNTL/BMAL1-deficient macrophages (By similarity).

Human, Mouse, Rat

Human,Mouse,Rat

-20°C,2°C to 8°C

41116161