Anti-Plakophilin 1 [10B2]

Absolute Antibody

Anti-Plakophilin 1 [10B2]

9

This antibody recognizes Plakophilin-1. It binds the epitope within the first 27 amino acids from the N-terminal region and it does not cross react with Plakophilin 2 and Plakophilin 3. Plakophilins influence development and participate in linking cadheri

10B2 is recommedned for the detection and analysis of Plakophilin-1. In order to identify potential perturbations in cell adherence, this antibody was used to detect plakophilin-1 in the skin tissue of patients with epidermolysis bullosa via immunofluorescence (Pigors et al., 2011; pmid: 21320868). Further, this antibody was demonstrated to have a potential diagnostic role in certain diseases, such as Ectodermal Dysplasia/Skin Fragility Syndrome where it was used to differentiate between a diseased and healthy skin samples (Sprecher et al., 2004; pmid: 15086548). It was also shown that 10B2 antibody can detect plakophilin-1 (PKP1) via Western blot (here: in HaCaT protein lysates) (Bonne et al., 2003; pmid: 12707304).

Flow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoHistoChemistry

Research Use Only

Monoclonal

10B2

PKP1

plakophilin 1

B6P; band 6 protein; EDSFS; plakophilin-1

Human

IgG1

Plakophilin-1

This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.

Human, Mouse

-20°C,2°C to 8°C

12352203