Anti-PLCG2 Antibody

HUABIO

Anti-PLCG2 Antibody

7

Flow Cytometry, ImmunoFluorescence, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

WB,IF-Cell,IHC-P,FC

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

PLCG2

phospholipase C gamma 2

APLAID, FCAS3, PLC-IV, PLC-gamma-2, 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2, phosphoinositide phospholipase C-gamma-2, phospholipase C, gamma 2 (phosphatidylinositol-specific), phospholipase C-IV

Rabbit

IgG

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2

Phosphoinositide-specific phospholipase C (PLC) plays a critical role in the initiation of receptor mediated signal transduction through the generation of the two second messengers, inositol 1,4,5-triphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate.There are many mammalian PLC isozymes, including PLC beta1, PLC beta2, PLC beta3, PLC beta4, PLC gamma1, PLC gamma2, PLC delta1, PLC delta2 and PLC e. After stimulation of the collagen receptor glycoprotein VI in human platelets, PLC gamma2 associates with several tyrosine-phosphorylated proteins (Syk, SLP-76, Lyn, linker for activation of T cells (LAT) and the FcR gamma chain), which bind to its C-terminal SH2 domain. PLC gamma1 associates with Syk in B cells, but PLC gamma2 does not associate with Syk in platelets. The C-terminal SH2 domain is involved in the regulation of PLC gamma2. In addition, Btk can induce PLC gamma2 tyrosine phosphorylation and initiate calcium moblization in CD72-stimulated B lymphocytes.

Human

Human

-20°C,2°C to 8°C

41116161