Anti-PODXL Antibody [D0-E8]

HUABIO

Anti-PODXL Antibody [D0-E8]

7

Western Blot

WB

Research Use Only

Monoclonal

D0-E8

2 mg/ml

Unconjugated

PODXL

podocalyxin like

Gp200, PC, PCLP, PCLP-1, PDX, PODXL1, gp135, podocalyxin, GCTM-2 antigen, podocalyxin-like protein 1

Mouse

IgG1

Podocalyxin

Podocalyxin, a sialoglycoprotein, is thought to be the major constituent of the glycocalyx of podocytes. It is a member of the CD34 family of transmembrane sialomucins. It is involved in the regulation of both adhesion and cell morphology and cancer progression. It functions as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Podocalyxin acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Sialylated, O-glycosylated glycoforms of podocalyxin expressed by colon carcinoma cells possess L-selectin and E-selectin binding activity, and may be pivotal to the metastatic spread of colon carcinoma cells

Human

Human

-20°C,2°C to 8°C

41116161