Anti-POVPC/PGPC [10C12]

Absolute Antibody

Anti-POVPC/PGPC [10C12]

7

This antibody is specific for oxidized phospholipids POVPC and PGPC. These are lipids play an important role in cardiovascular disease.

When injected in ApoE KO mice, the mouse version of this antibody decreased accumulation of macrophages in the brachiocephalic artery and decreased OxPL-induced inflammatory response (Cherepanova and Owens, 2014). To study the binding of its ligands a surface plasmon resonance experiment was preformed on POVPC, PGPC and DMPC using the mouse version of this antibody. Modified Russell-Movat (Movat) staining for morphometric analysis of the brachiocephalic arteries was preformed using the mouse version of this antibody. To confirm the binding of this antibody to POVPC and PGPC an ELISA was preformed (Cherepanova et al, 2019; pmid:31645128).

Functional Assay, ImmunoFluorescence, ELISA, Other Application

functional assay; SPR; IF; ELISA

Research Use Only

Monoclonal

10C12

Rabbit

IgG

This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgM format, for improved compatibility with existing reagents, assays and techniques.

Other Species

Species independent

The mouse version of this antibody was generated by feeding an ApoE KO mice with a high-fat western diet.

-20°C,2°C to 8°C

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