Anti-PP2A alpha + beta Antibody [A0-G7]

HUABIO

Anti-PP2A alpha + beta Antibody [A0-G7]

7

Flow Cytometry, ImmunoFluorescence, Western Blot

WB,IF-Cell

Research Use Only

Monoclonal

A0-G7

2 mg/ml

Unconjugated

PPP2CA

protein phosphatase 2 catalytic subunit alpha

HJS3, NEDLBA, PP2Ac, PP2CA, PP2Calpha, RP-C, serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform, PP2A-alpha, protein phosphatase 2, catalytic subunit, alpha isozyme, replication protein C

Mouse

IgG1

Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGOL2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53. Dephosphorylates SV40 large T antigen, preferentially on serine residues 120, 123, 677, and perhaps 679. The C subunit was most active, followed by the AC form, which was more active than the ABC form, and activity of all three forms was strongly stimulated by manganese, and to a lesser extent by magnesium. Dephosphorylation by the AC form, but not C or ABC form is inhibited by small T antigen. Activates RAF1 by dephosphorylating it at Ser-259.

Human, Mouse, Rat

Human,Mouse,Rat

-20°C,2°C to 8°C

41116161