Anti-PRC1 Mouse mAb

PTM BIO

Anti-PRC1 Mouse mAb

5

Western Blot, ImmunoHistoChemistry Paraffin

WB, IHC-P

Research Use Only

Monoclonal

10834

Unconjugated

Mouse

IgG

Protein regulator of cytokinesis 1

Protein Regulator of Cytokinesis 1 (PRC1) is a member of the MAP65/ASE1 family of nonmotor microtubule-associated proteins, first described in budding yeast. PRC1 is a substrate of CDK1, which maintains PRC1 in an inactive, monomeric state. Cell-cycle dependent degradation of CDK1 leads to dePhosphorylatedrylation of PRC1 and subsequent KIF4-mediated translocation to the plus ends of microtubules, where it promotes microtubule bundling by cross-linking antiparallel microtubules. The microtubule bundling functions of PRC1 play a critical role in maintaining structural integritry of the spindle midzone during cytokinesis.

Stable for 12 months from date of receipt/reconstitution.

Human

Human

Protein A purified

Store at -20°C. Avoid freeze/thaw cycles.

12352203