Anti-PRMT5 Rabbit mAb

PTM BIO

Anti-PRMT5 Rabbit mAb

5

ImmunoPrecipitation, Western Blot, ImmunoHistoChemistry Paraffin

WB, IHC-P, IP

Research Use Only

Monoclonal

13598

Unconjugated

Rabbit

IgG

Protein arginine N-methyltransferase 5

Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Methylates SUPT5H and may regulate its transcriptional elongation properties. Mono- and dimethylates arginine residues of myelin basic protein (MBP) in vitro. May play a role in cytokine-activated transduction pathways. Negatively regulates cyclin E1 promoter activity and cellular proliferation. Methylates histone H2A and H4 'Arg-3' during germ cell development. Methylates histone H3 'Arg-8', which may repress transcription. Methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage.

Stable for 12 months from date of receipt/reconstitution.

Human

Protein A purified

Store at -20°C. Avoid freeze/thaw cycles.

12352203