Anti-PRR5 Antibody

HUABIO

Anti-PRR5 Antibody

2

Western Blot

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

PRR5

proline rich 5

FLJ20185k, PP610, PROTOR-1, PROTOR1, proline-rich protein 5, Rho GTPase activating protein 8, proline rich 5 (renal), protein observed with Rictor-1

Rabbit

IgG

Proline-rich protein 5

Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 Ser-473 phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on Thr-308 by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at Ser-422. mTORC2 also modulates the phosphorylation of PRKCA on Ser-657. PRR5 plays an important role in regulation of PDGFRB expression and in modulation of platelet-derived growth factor signaling. May act as a tumor suppressor in breast cancer.

-20°C,2°C to 8°C

41116161