Anti-PSMC5 Antibody [PSH0-22]

HUABIO

Anti-PSMC5 Antibody [PSH0-22]

2

Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Monoclonal

PSH0-22

1 mg/ml

Unconjugated

PSMC5

proteasome 26S subunit, ATPase 5

RPT6, S8, SUG-1, SUG1, TBP10, TRIP1, p45, p45/SUG, 26S proteasome regulatory subunit 8, 26S protease regulatory subunit 8, 26S proteasome AAA-ATPase subunit RPT6, MSUG1 protein, Tat-binding protein homolog 10, proteasome (prosome, macropain) 26S subunit, ATPase, 5, proteasome 26S ATPase subunit 5, proteasome subunit p45, testicular tissue protein Li 149, thyroid hormone receptor-interacting protein 1, thyroid receptor interactor 1

Rabbit

IgG

26S proteasome regulatory subunit 8

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. In addition to participation in proteasome functions, this subunit may participate in transcriptional regulation since it has been shown to interact with the thyroid hormone receptor and retinoid X receptor-alpha. Two transcript variants encoding different isoforms have been found for this gene.

-20°C,2°C to 8°C

41116161